Did you know that over 70% of new drug molecules face significant bioavailability challenges?
The Paradigm Shift in Pharma
With over 30% of active pharmaceutical ingredients (APIs) requiring micronization and a rising demand in high-potency APIs (HPAPIs), particularly in oncology, the industry is witnessing a fundamental transformation. But why has particle size reduction become so crucial?
Understanding Micronization: Beyond Size Reduction
It’s not just about making things smaller. Micronization is revolutionizing drug development through:
- Enhanced API solubility and bioavailability
- Optimized particle properties for targeted delivery
- Precision-engineered solutions for inhalation products
- Transformed physical attributes for better formulation
The Science Behind the Success
By reducing particle size to micron levels, micronization increases surface area, promoting faster dissolution and absorption rates. This is particularly crucial for poorly soluble drugs, where bioavailability challenges often limit therapeutic effectiveness.
The Biopharmaceutical Classification System (BCS) influences modern pharmaceutical development:
- Micronization is essential for Class II drugs.
- To improve the interaction between the drug’s solubility and permeability.
- Strategic approaches for each drug class
- There are optimization techniques for challenging compounds.
The Big Impact of Going Small
In today’s pharmaceutical landscape, understanding BCS classification and micronization techniques isn’t just valuable—it’s essential. As solubility and bioavailability challenges continue to shape drug development, AGC Pharma Chemical’s innovative Hosokawa-Alpine micronization technology is key to ensuring that a drug successfully reaches the market. The CDMO (Contract Development and Manufacturing Organization) specializing in the production and development of API and intermediate processes, based in Barcelona and Japan, offers a groundbreaking dual solution by combining opposed jet milling and mechanical impact milling in a single sophisticated system.
Whether you’re developing new formulations or seeking to enhance existing ones Ready to revolutionize your particle size reduction process?
Contact with the expert team to discover how AGC Pharma Chemicals’s advanced micronization capabilities can transform your drug development process.
